Introduction to the Second Lecture: Secondary Headache
In the name of Allah, we rely on Allah. Peace be upon you and the mercy of Allah and His blessings. This is the second lecture, God willing, on the topic of headaches. In the previous lecture, we discussed the general objectives and the warning signs (Red Flags), as well as primary headache disorders such as migraines (Migraine), tension headaches (Tension Headache), and cluster headaches (Cluster Headache).
In this lecture, God willing, we will discuss secondary headache disorders (Secondary Headache Disorders), which are headaches caused by another medical condition.
Case Study
I will start with the case I sent you on the group, which is a patient I saw two days ago in the hospital. She is 65 years old and has no previous health problems. She complained of a headache on the right side, with moderate severity (7 out of 10). The neurological exam was normal; there was no weakness in the limbs or clear neurological changes.
The only observation was a slight protrusion in her right eye (Eye Bulging). When I asked her daughter, she confirmed that this protrusion was new and had appeared in the past six weeks. In medicine, there is what is called "spot diagnosis," where you build a differential diagnosis (Differential Diagnosis) just by seeing the patient.
Based on the examination, the first thought was the presence of a tumor (Tumor). Indeed, we performed an MRI (Magnetic Resonance Imaging) of the brain, and it showed a large tumor of 49 mm that was pressing on the eye and pushing it outward.
Importance of Warning Signs (Red Flags)
In this case, there was a very clear "red flag," which was the age (Age). Any new headache (New Onset Headache) that appears in a patient over the age of fifty is a warning sign that requires thorough examination (Workup) to ensure that there is no secondary cause.
One of the options suggested in the group was "hyperthyroidism" (Hyperthyroidism), but eye protrusion in hyperthyroidism is usually in both eyes (Bilateral), while in our case it was in one side (Unilateral), which directs us more towards neurological causes or tumors.
Causes of Secondary Headache (Differential Diagnosis)
Secondary headaches account for about 11% of headache cases, and early diagnosis is necessary to avoid serious complications. The main causes include:
- Brain Bleeding: Such as hemorrhagic stroke (Hemorrhagic Stroke) or subarachnoid hemorrhage (Subarachnoid Hemorrhage).
- Inflammatory: Such as temporal arteritis (Temporal Arteritis).
- Tumors (Brain Tumors): Masses that cause pressure within the skull.
- Sinus Venous Thrombosis.
- Intracranial Pressure Disorders: Whether idiopathic intracranial hypertension (IIH) or low cerebrospinal fluid pressure (Low CSF Pressure).
- Infections: Such as meningitis (Meningitis) or brain abscess (Brain Abscess).
- Systemic Causes: Such as severe hypertension, anemia, or sleep apnea (Sleep Apnea).
- Eye and Dental Problems: Such as glaucoma (increased eye pressure) or dental problems.
- Medication Overuse Headache.
- Neck Muscle Spasm.
Detailed Clinical Cases
1. Idiopathic Intracranial Hypertension (IIH / Pseudotumor Cerebri)
This condition typically affects young overweight women (Obese). Sometimes, it is caused by the consumption of vitamin A or certain antibiotics such as tetracycline.
- Symptoms: Continuous headache for weeks, blurred vision, and tinnitus.
- Examination: Shows swelling of the optic nerve in both eyes (Bilateral Papilledema).
- Diagnosis: Requires an MRI (Magnetic Resonance Imaging) and venography (MRV) to rule out tumors and clots, followed by a lumbar puncture (Lumbar Puncture) to measure pressure.
- Treatment: The drug "Diamox" (Diamox), weight loss, and stopping the causative medications.
2. Temporal Arteritis (Temporal Arteritis)
This is an emergency condition as it can lead to permanent vision loss.
- Symptoms: Headache in the temporal region, tenderness (Tenderness), jaw pain when chewing, and temporary vision loss.
- Diagnosis: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) tests, and confirmation of diagnosis by biopsy of the temporal artery.
- Treatment: Immediate initiation of high doses of steroids (Prednisone) even before the biopsy results to protect vision.
3. Low Cerebrospinal Fluid Pressure Headache
Characterized by being a "positional headache" (Positional Headache), meaning it worsens when standing or sitting and improves when lying down. It often occurs after the patient is exposed to a blow or after a lumbar puncture procedure (Post-LP headache). It is treated with rest, fluids, caffeine, or an "epidural blood patch" (Epidural Blood Patch).
4. Medication Overuse Headache (Rebound Headache)
This condition is very common among migraine patients (Migraine). When the patient starts taking painkillers such as "Tylenol" or "Ibuprofen" excessively (more than 10-15 days per month), the headache turns into a chronic daily headache.
- Diagnosis: The doctor should ask the patient detailed questions; are all headache episodes of the same severity? Often, the patient describes two types of headaches: severe migraine attacks and another headache that is milder but continuous.
- Treatment: The basic solution is to gradually stop the painkillers that caused the condition and start preventive treatments for migraines (Preventive Therapy) such as Botox or other specific medications.
When to Request Advanced Tests? (Diagnostic Hints)
Not every headache shows results on a regular CT scan (CT Scan). There are cases where the CT scan is normal but the patient is at risk:
- Subarachnoid Hemorrhage: If the CT scan is negative and we clinically suspect it (the worst headache of one's life), we resort to a lumbar puncture (Lumbar Puncture) to look for blood traces in the cerebrospinal fluid.
- Important Note: It is preferable to wait 6 hours from the onset of the headache before performing the lumbar puncture to ensure the accuracy of the result.
- Arterial Dissection: Requires a CT angiogram (CT Angiogram).
- Sinus Thrombosis: Requires venography (MRV).
- Meningitis: Requires a lumbar puncture to examine cells and culture, and it does not appear on CT scans.
Discussion of Cases and Final Questions
Headache with Fever
A patient comes with a headache and fever (Fever) and elevated white blood cells. The first step is to rule out infection in the central nervous system (CNS Infection).
- Procedure: We perform a CT scan of the brain first to ensure there is no mass causing pressure (to avoid brain herniation/Herniation), then we follow it directly with a lumbar puncture.
The Role of Caffeine in Headaches
Caffeine is a double-edged sword; it is included in some headache medications (such as Excedrin or Fioricet) and helps in treating low cerebrospinal fluid pressure headaches. However, at the same time, caffeine is a trigger for migraine attacks in some patients, and sudden withdrawal from it causes "caffeine withdrawal headache."
Final Advice
Accurate diagnosis is the key to treatment. It is essential to link the medical history with age and clinical symptoms. Any change in the pattern of the headache, the appearance of visual symptoms, protrusion of the eye, or a headache that begins after the age of fifty, should be taken very seriously and not diagnosed as a primary headache unless secondary serious causes are ruled out.
With this, we have concluded this educational journey on the topic of headaches. We ask God to benefit us and you, and for this knowledge to be purely for His noble countenance. May God reward you for your good listening and interaction, and we will meet in future lectures, if God wills.
Peace be upon you and the mercy of God and His blessings.